Cryoablation Without Excision for Early-Stage Breast Cancer: ICE3 Trial 5-Year Follow-Up on Ipsilateral Breast Tumor Recurrence

Authors

Richard E. Fine, Margaret West Comprehensive Breast Center, West Cancer Center and Research Institute, Germantown, TN, USA. rfine@westclinic.com.
Richard C. Gilmore, Margaret West Comprehensive Breast Center, West Cancer Center and Research Institute, Germantown, TN, USA.
Kenneth R. Tomkovich, CentraState Medical Center, Freehold, NJ, USA.
Jill R. Dietz, University Hospital Cleveland Medical Center, Cleveland, OH, USA.
Michael P. Berry, Margaret West Comprehensive Breast Center, West Cancer Center and Research Institute, Germantown, TN, USA.
Lydia E. Hernandez, Cincinnati Breast Surgeons Inc, Cincinnati, OH, USA.
Karen S. Columbus, Cincinnati Breast Surgeons Inc, Cincinnati, OH, USA.
Susan A. Seedman, Presbyterian Cancer Center, Rio Rancho, NM, USA.
Carla S. Fisher, Indiana University IU Health Hospital-University Hospital, Indianapolis, IN, USA.
Linda K. Han, Indiana University IU Health Hospital-University Hospital, Indianapolis, IN, USA.
Eric R. Manahan, Dalton Surgical Group, Dalton, GA, USA.
Randy D. Hicks, Regional Medical Imaging, Flint, MI, USA.
Rashmi P. Vaidya, Ironwood Cancer and Research Centers, Glendale, AZ, USA.
Lisa D. Curcio, BreastLink Laguna Hills, Laguna Hills, CA, USA.
Alexander B. Sevrukov, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Andrew S. Kenler, Bridgeport Hospital, Bridgeport, CT, USA.
Bret Taback, Columbia University Medical Center, New York, NY, USA.
Margaret Chen, Columbia University Medical Center, New York, NY, USA.
Megan E. Miller, University Hospital Cleveland Medical Center, Cleveland, OH, USA.
Linsey Gold, Comprehensive Breast Care, Troy, MI, USA.
Beth V. Anglin, Complete Breast Care, Plano, TX, USA.
Hussein D. Aoun, Karmanos Cancer Institute, Detroit, MI, USA.
Rache M. Simmons, Weill Cornell Weill Medical College, Cornell University, New York, NY, USA.
Sheldon M. Feldman, Montefiore-Einstein Center for Cancer Care, New York, NY, USA.
Susan K. Boolbol, Mount Sinai Beth Israel, New York, NY, USA.Follow

Document Type

Article

Publication Title

Annals of surgical oncology

Abstract

BACKGROUND: The ICE3 trial evaluated the safety and efficacy of cryoablation in women aged ≥60 years with low-risk, early-stage breast cancers, aiming to provide a non-operative treatment option and avoid potential surgical risks. This study presents 5-year follow-up trial results. METHODS: The ICE3 trial is an Institutional Review Board-approved, prospective, multicentered, non-randomized trial including women ≥ 60 years of age with unifocal, ultrasound visible, invasive ductal carcinoma ≤ 1.5 cm in size, histologic grade 1-2, hormone receptor (HR)-positive, and human epidermal growth factor receptor 2 (HER2)-negative. The primary study endpoint of 5-year ipsilateral breast tumor recurrence (IBTR) was evaluated based on Kaplan-Meier estimates. RESULTS: Overall, 194 patients meeting eligibility received successful cryoablation treatment per protocol and were included for analysis. The mean age was 74.9 years (55-94) with a mean tumor size of 7.4 mm transverse (2.8-14.0 mm) and 8.1 mm sagittal (2.5-14.9 mm). With a mean follow-up period of 54.16 months, the IBTR rate at 5 years was 4.3% and breast cancer survival was 96.7%. Of the 124 patients who received endocrine therapy only, the IBTR was 3.7%. No serious device-related adverse events were reported. Minor (88.2%) and moderate (9.6%) adverse events were mild in severity and resolved without residual effects. Quality-of-life score demonstrated statistically significant improvement (p < 0.001) in distress at 6 months as compared with baseline. CONCLUSIONS: Breast cryoablation presents a promising alternative to surgery in selected patients, offering the benefits of a minimally invasive procedure with minimal risks. Further studies are encouraged to confirm cryoablation as a viable alternative to surgical excision low-risk patients.

First Page

7273

Last Page

7283

DOI

10.1245/s10434-024-16181-0

Publication Date

10-1-2024

Identifier

39283572 (pubmed); PMC11452421 (pmc); 10.1245/s10434-024-16181-0 (doi); 10.1245/s10434-024-16181-0 (pii)

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