OncoSexome: the landscape of sex-based differences in oncologic diseases
Document Type
Article
Publication Title
Nucleic acids research
Abstract
The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-based differences in precision oncology. Over 50% of clinically actionable oncology genes are sex-biased, indicating differences in drug efficacy. Research has identified sex differences in non-reproductive cancers, highlighting the need for comprehensive sex-based cancer data. We therefore developed OncoSexome, a multidimensional knowledge base describing sex-based differences in cancer (https://idrblab.org/OncoSexome/) across four key topics: antineoplastic drugs and responses (SDR), oncology-related biomarkers (SBM), risk factors (SRF) and microbial landscape (SML). SDR covers sex-based differences in 2051 anticancer drugs; SBM describes 12 551 sex-differential biomarkers; SRF illustrates 350 sex-dependent risk factors; SML demonstrates 1386 microbes with sex-differential abundances associated with cancer development. OncoSexome is unique in illuminating multifaceted influences of biological sex on cancer, providing both external and endogenous contributors to cancer development and describing sex-based differences for the broadest oncological classes. Given the increasing global research interest in sex-based differences, OncoSexome is expected to impact future precision oncology practices significantly.
DOI
10.1093/nar/gkae1003
Publication Date
11-13-2024
Recommended Citation
Shen, Xinyi; Zhang, Yintao; Li, Jiamin; Zhou, Ying; Butensky, Samuel D.; Zhang, Yechi; Cai, Zongwei; DeWan, Andrew T.; Khan, Sajid A.; Yan, Hong; Johnson, Caroline H.; and Zhu, Feng, "OncoSexome: the landscape of sex-based differences in oncologic diseases" (2024). Surgery. 222.
https://scholar.bridgeporthospital.org/surgery/222
Identifier
39535034 (pubmed); 10.1093/nar/gkae1003 (doi); 7899531 (pii)