Pulmonary hypertension in end-stage renal disease

Authors

Joe Devasahayam, Division of Pulmonary Critical Care Medicine, University of South Dakota Sanford School of Medicine, E Clark St, Vermillion, SD, 57069, USA.
Tony Oliver, Department of Internal Medicine, University of South Dakota Sanford School of Medicine, E Clark St, Vermillion, SD, 57069, USA.
Valentina Joseph, Division of Neurology, University of South Dakota Sanford School of Medicine, E Clark St, Vermillion, SD, 57069, USA.
Sudheer Nambiar, Division of Pulmonary Critical Care Medicine, Cancer Treatment Centers of America, 10109 E. 79th St., Tulsa, OK, 74133, USA.
Kulothungan Gunasekaran, Division of Pulmonary Critical Care Medicine, Yale-New Haven Health Bridgeport Hospital, 267 Grant Street, CT, 06610, USA. Electronic address: kulothungan.gunasekaran@bpthosp.org.

Document Type

Article

Publication Title

Respiratory medicine

Abstract

Pulmonary hypertension associated with end-stage renal disease (ESRD) is an important yet under-recognized condition and can lead to life-threatening complications. The pathogenesis of pulmonary hypertension is peculiar in ESRD, and understanding it is important to recognize such patients at the earliest and commence appropriate treatment. Many studies have discovered the prevalence of pulmonary hypertension to be up to 80% in ESRD and have been associated with increased mortality. WHO has classified pulmonary hypertension in renal failure to be in group 5, a group defined by unclear multifactorial etiologies. Moreover, there is an improvement with renal transplant and closure of AV fistula, thus confirming the contribution from these. The pharmacological management of pulmonary hypertension in this unique population is not very different from other etiologies. However, one should understand that pulmonary hypertension as such, could be multifactorial, and other secondary causes of pulmonary hypertension should also be recognized and treated accordingly. In this article, we will discuss the concept of pulmonary hypertension in ESRD in detail and the options of treatment.

First Page

105905

DOI

10.1016/j.rmed.2020.105905

Publication Date

4-1-2020

Recommended Citation

Devasahayam, Joe; Oliver, Tony; Joseph, Valentina; Nambiar, Sudheer; and Gunasekaran, Kulothungan, "Pulmonary hypertension in end-stage renal disease" (2020). All Research. 162.
https://scholar.bridgeporthospital.org/all_research/162

Identifier

32094103 (pubmed); 10.1016/j.rmed.2020.105905 (doi); S0954-6111(20)30045-7 (pii)