Clinical consequences of altered chemoreflex control

Document Type

Article

Publication Title

Respiratory physiology & neurobiology

Abstract

Control of ventilation dictates various breathing patterns. The respiratory control system consists of a central pattern generator and several feedback mechanisms that act to maintain ventilation at optimal levels. The concept of loop gain has been employed to describe its stability and variability. Synthesizing all interactions under a general model that could account for every behavior has been challenging. Recent insight into the importance of these feedback systems may unveil therapeutic strategies for common ventilatory disturbances. In this review we will address the major mechanisms that have been proposed as mediators of some of the breathing patterns in health and disease that have raised controversies and discussion on ventilatory control over the years.

First Page

354

Last Page

63

DOI

10.1016/j.resp.2013.04.020

Publication Date

11-1-2013

Identifier

23681082 (pubmed); NIHMS664852 (mid); PMC4336771 (pmc); 10.1016/j.resp.2013.04.020 (doi); S1569-9048(13)00125-0 (pii)

This document is currently not available here.

Share

COinS