Severe desquamating disorder after liver transplant: toxic epidermal necrolysis or graft versus host disease?

Document Type

Article

Publication Title

Journal of burns and wounds

Abstract

OBJECTIVE: The objective of this article is to present and discuss the clinical characteristics of TEN (Toxic Epidermal Necrolysis) and GVHD (Graft Versus Host Disease) following orthotopic liver transplantation. METHODS: Recent experience with a patient who suffered a fatal desquamation syndrome within weeks of liver transplantation provides the basis for a discussion of differential diagnosis of these two conditions. RESULTS: TEN and GVHD demonstrate similar clinical presentations as well as etiology (CD8+ lymphocyte attack on epithelial surfaces). This case demonstrates the difficulty in distinguishing between these two conditions in this particular patient. CONCLUSIONS: Advances in the understanding and treatment of one of these disease states may provide therapeutic insights into the other.

First Page

e1

Publication Date

1-28-2006

Identifier

16921414 (pubmed); PMC1687152 (pmc)

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