Gut microbiota interventions in type 2 diabetes mellitus: An umbrella review of glycemic indices

Authors

Mohammad-Hossein Keivanlou, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Ehsan Amini-Salehi, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Follow
Nazila Sattari, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Mohammad Hashemi, Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Parsa Saberian, Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Shrinidhi Vilas Prabhu, Kasturba Medical Collage Mangaluru, DK, Karnataka, India.
Mona Javid, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Arian Mirdamadi, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Forough Heidarzad, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Arash Bakhshi, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.Follow
Negin Letafatkar, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Reza Zare, Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran.
Soheil Hassanipour, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: soheil.epid@gmail.com.
Sandeep Samethadka Nayak, Department of Internal Medicine, Yale New Haven Health Bridgeport Hospital , Bridgeport, CT, USA.

Document Type

Article

Publication Title

Diabetes & metabolic syndrome

Abstract

BACKGROUND: We aimed to explore how probiotics, prebiotics, or synbiotics impact glycemic indices in patients with diabetes mellitus. METHOD: A comprehensive search was conducted on PubMed, Scopus, and Web of Science from inception up to April 2023. The random-effects model was employed for the study analysis. Furthermore, sensitivity and subgroup analyses were conducted to investigate potential sources of heterogeneity. AMSTAR2 checklist was used to determine the quality of studies. Comprehensive meta-analysis version 3 was used for the study analysis. RESULT: A total of 31 studies were included in the final analysis. Based on the results of the meta-analysis, gut microbial therapy could significantly decrease serum fasting blood glucose levels in patients with type 2 diabetes mellitus (effect size: -0.211; 95 % CI: -0.257, -0.164; P < 0.001). Additionally, significant associations were also found between gut microbial therapy and improved serum levels of fasting insulin, glycated hemoglobin, and homeostatic model assessment for insulin resistance (effect size: -0.087; 95 % confidence interval: -0.120, -0.053; P < 0.001; effect size: -0.166; 95 % confidence interval: -0.200, -0.132; P < 0.001; effect size: -0.230; 95 % confidence interval: -0.288, -0.172; P < 0.001, respectively). CONCLUSION: Our results revealed promising effects of gut microbiota modulation on glycemic profile of patients with type 2 diabetes mellitus. The use of these agents as additional treatments can be considered.

First Page

103110

DOI

10.1016/j.dsx.2024.103110

Publication Date

8-1-2024

Recommended Citation

Keivanlou, Mohammad-Hossein; Amini-Salehi, Ehsan; Sattari, Nazila; Hashemi, Mohammad; Saberian, Parsa; Prabhu, Shrinidhi Vilas; Javid, Mona; Mirdamadi, Arian; Heidarzad, Forough; Bakhshi, Arash; Letafatkar, Negin; Zare, Reza; Hassanipour, Soheil; and Nayak, Sandeep Samethadka, "Gut microbiota interventions in type 2 diabetes mellitus: An umbrella review of glycemic indices" (2024). All Research. 5.
https://scholar.bridgeporthospital.org/all_research/5

Identifier

39213690 (pubmed); 10.1016/j.dsx.2024.103110 (doi); S1871-4021(24)00171-1 (pii)