Primary uterine osteosarcoma arising in a leiomyoma with rapid local recurrence: A case report

Document Type

Article

Publication Title

Gynecologic oncology reports

Abstract

BACKGROUND: Extraskeletal osteosarcoma is an extremely rare malignant neoplasm. Literature regarding primary osteosarcoma of the uterus is confined to only a small number of case reports : A 57-year-old female with a history of uterine fibroids presented to the emergency department with abdominal pain. Imaging was notable for an enlarged uterus with a 15 cm calcified fibroid extending along the posterior uterus. The patient underwent a laparotomy for total hysterectomy and bilateral salpingo-oophorectomy. Pathological evaluation of the specimen yielded mesenchymal proliferation with osteoid formation and tumor cells with densely eosinophilic cytoplasm resembling osteoblasts with a final diagnosis of primary uterine osteosarcoma. Multidisciplinary tumor board recommended against adjuvant treatment, given the lack of evidence for improved outcomes for early-stage uterine sarcomas. The patient was followed up with surveillance visits every-three months, entailing physical examination and computed tomography(CT) scans. Unfortunately, she had locoregional oligometastatic recurrence of her disease at 1-year follow up. CONCLUSION: Primary uterine osteosarcoma is an extremely rare and aggressive neoplasm with limited understanding regarding optimal treatment options.

First Page

101102

DOI

10.1016/j.gore.2022.101102

Publication Date

12-1-2022

Identifier

36405307 (pubmed); PMC9672400 (pmc); 10.1016/j.gore.2022.101102 (doi); S2352-5789(22)00182-5 (pii)

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