Wide Spectrum of Flecainide Toxicity: A Case Report and Literature Review

Authors

Anton Stolear, Cardiology, Yale University/Bridgeport Hospital, Bridgeport, USA.Follow
Maxim Dulgher, Internal Medicine, Nuvance Health/Norwalk Hospital, Norwalk, USA.Follow
Ju Young Bae, Cardiology, Yale University/Bridgeport Hospital, Bridgeport, USA.Follow
Lila Kaminsky, Cardiology, Yale University/Bridgeport Hospital, Bridgeport, USA.Follow
Gini P. Jeyashanmugaraja, Cardiology, Yale University/Bridgeport Hospital, Bridgeport, USA.Follow
Uzodinma Emerenini, Cardiac Electrophysiology, Yale New Haven Health/Bridgeport Hospital, Bridgeport, USA.

Document Type

Article

Publication Title

Cureus

Abstract

Flecainide toxicity is a rare but serious condition that can present with a wide range of clinical symptoms. We report the case of a 79-year-old female with paroxysmal atrial fibrillation on flecainide therapy who developed altered mental status, visual hallucinations, and bradycardia. Laboratory results revealed an acute kidney injury, which contributed to elevated flecainide levels. Discontinuation of flecainide led to a rapid resolution of symptoms and normalization of ECG findings. This case underscores the critical need for careful monitoring of renal function and potential drug interactions in patients receiving flecainide to prevent toxicity, highlighting the wide range of flecainide toxicity, including rare manifestations such as encephalopathy and visual hallucinations.

First Page

e62923

DOI

10.7759/cureus.62923

Publication Date

6-1-2024

Recommended Citation

Stolear, Anton; Dulgher, Maxim; Bae, Ju Young; Kaminsky, Lila; Jeyashanmugaraja, Gini P.; and Emerenini, Uzodinma, "Wide Spectrum of Flecainide Toxicity: A Case Report and Literature Review" (2024). Cardiology. 82.
https://scholar.bridgeporthospital.org/cardiology/82

Identifier

39040749 (pubmed); PMC11262768 (pmc); 10.7759/cureus.62923 (doi)