Comparison of 30-Day Readmission Between Early and Late Catheter Directed Thrombolysis for Acute Pulmonary Embolism in the United States

Authors

Kawabena Sarpong, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;
Sun-Joo Jang, Department of Medicine, Yale School of Medicine, United States.
Mary Quien, Department of Cardiology, Bridgeport Hospital, Bridgeport, Connecticut.
Karthik Mathialagan, Department of Medicine, Yale-New Haven Health-Bridgeport Hospital, Bridgeport, CT.
Abhinav Aggarwal, Department of Internal Medicine, Yale New Haven Health, Bridgeport Hospital, Bridgeport, CT 06605, USA.Follow
Ilhwan Yeo, Division of Cardiology, New York Presbyterian Queens Hospital, New York, NY 11355, USA.
Kavitha Gopalratnam, Department of Internal Medicine, Bridgeport Hospital/Yale University School of Medicine, Bridgeport, Connecticut.

Document Type

Article

Publication Title

Journal of Cardiovascular Development and Disease

Abstract

Background: Pulmonary embolism (PE) is a major cause of morbidity and mortality accounting for 100,000 deaths per year in the United States and 5–10% of in-hospital deaths. There is sparse comparative data on readmission patterns in patients who undergo early versus late catheter directed thrombolysis (CDT) for acute PE. Research Question: Is the procedure day for acute PE associated with a difference in 30-day readmission rates? Study Design and Method: This study was performed by using the Nationwide Readmissions Database between 2016 and 2019. Patients with acute PE who underwent CDT were identified using codes from the International Classification of Diseases, 10th Edition (ICD 10). Results: The 30-day readmission rates were higher for patients who underwent CDT on Day 2 or afterwards compared to Day 1 and Day 0 (7.1% vs. 5.7% vs. 5.2%). Patients who had CDT on Day 2 or later had a higher rate of 30-day readmission mortality compared to those who had CDT on Day 1 or 0 (0.6% vs. 0.3% vs. 0.2%. The 30-day readmission rates for heart failure were higher among patients who had CDT on Day 2 compared to those who had CDT on Day 0 of admission (2% vs. 1.0% vs. 0.9%). Interpretation: Delayed CDT for acute PE was associated with increased rates of 30-day readmission, readmission mortality, and readmission for heart failure. These findings emphasize the need for earlier CDT for the treatment of acute PE.

DOI

https://doi.org/10.3390/jcdd12040118

Publication Date

3-27-2025

Recommended Citation

Nketiah Sarpong KS, Jang SJ, Quien M, Muralidharan K, Aggarwal A, Yeo I, Gopalratnam K. Comparison of 30-Day Readmission Between Early and Late Catheter Directed Thrombolysis for Acute Pulmonary Embolism in the United States. J Cardiovasc Dev Dis. 2025 Mar 27;12(4):118. doi: 10.3390/jcdd12040118.

e-ISSN

2308-3425