Research trends in CAR-T cell therapy: A comprehensive bibliometric analysis highlighting cardiovascular toxicity and clinical implications

Authors

Daniyal Ameen, Department of Internal Medicine, Yale New Haven Health Bridgeport Hospital, Bridgeport, CT.
Ehsan Amini-Salehi, School of Medicine, Guilan University of Medical Science, Rasht, Iran.Follow
Sandeep Samethadka Nayak, Department of Internal Medicine, Yale New Haven Health Bridgeport Hospital, Bridgeport, CT.Follow
Ashraf Ahmed, Department of Internal Medicine, Yale New Haven Health Bridgeport Hospital, Bridgeport, CT.Follow
Alexis Pudimat, University of Bridgeport, Bridgeport, CT.
Amir Nasrollahizadeh, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Follow
Kaveh Hosseini, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Seyedeh Fatemeh Hosseini Jebelli, Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran.
Azin Alizadeh Asl, Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran.
Anthony Loc Nguyen, Division of Hematology/Oncology, Department of Internal Medicine, UC San Diego Health Moores Cancer Center, San Diego, CA.

Document Type

Article

Publication Title

Medicine

Abstract

BACKGROUND: Chimeric antigen receptor T cell (CAR-T) therapy is an innovation in oncology, which provides targeted treatment alternatives for certain tumors. CAR-T therapy has been associated to adverse cardiovascular consequences despite its potential for therapeutic benefit. As research in this field expands rapidly, a bibliometric study is needed to map the current state of knowledge and highlight emerging areas of interest to guide future studies and optimize patient outcomes. METHODS: A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection and PubMed to examine the literature on CAR-T cell therapy and its cardiovascular implications. RESULTS: The annual number of publications on CAR-T therapy and cardiovascular symptoms has steadily increased, experiencing a significant surge starting in 2018. The USA, China, and Germany emerged as the leading contributors. Key journals included Frontiers in Immunology and Blood, while highly cited journals were Lancet Oncology and the Journal of Clinical Oncology. Keyword analysis identified multiple myeloma, immunotherapy, and cytokine release syndrome as major research themes. The clustered map highlighted interconnected research areas, with a significant focus on multiple myeloma, combination therapy, cardiovascular magnetic resonance assessment, and novel therapeutic approaches. CONCLUSION: This bibliometric analysis provided a detailed overview of the research landscape on CAR-T cell therapy and its cardiovascular implications, identifying trends and gaps in knowledge. Recent research trends highlighted bispecific antibodies, CAR-T cell therapy, cardiovascular events, lymphoma, management, and outcomes as emerging focus areas. These keywords underscore the developing field of cardiac events, management, and outcomes in patients undergoing CAR-T cell therapy.

First Page

e42314

DOI

10.1097/MD.0000000000042314

Publication Date

5-16-2025

Recommended Citation

Ameen, Daniyal; Amini-Salehi, Ehsan; Nayak, Sandeep Samethadka; Ahmed, Ashraf; Pudimat, Alexis; Nasrollahizadeh, Amir; Hosseini, Kaveh; Hosseini Jebelli, Seyedeh Fatemeh; Alizadeh Asl, Azin; and Nguyen, Anthony Loc, "Research trends in CAR-T cell therapy: A comprehensive bibliometric analysis highlighting cardiovascular toxicity and clinical implications" (2025). Internal Medicine. 246.
https://scholar.bridgeporthospital.org/internal_medicine/246

Identifier

40388795 (pubmed); PMC12091642 (pmc); 10.1097/MD.0000000000042314 (doi); 00005792-202505160-00076 (pii)