Institutional review of primary non-hodgkin lymphoma of the female genital tract: a 33-year experience
Document Type
Article
Publication Title
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Abstract
OBJECTIVE: The aim of this is to provide an updated review of the literature and to report our institutional experience with this rare gynecologic malignancy. METHODS: The medical records of patients with diagnosis of non-Hodgkin lymphoma of the female genital tract from 1980 to 2013 at the Yale-New Haven Hospital were reviewed retrospectively. Histological classification and staging were determined by the World Health Organization and Ann Arbor systems, respectively. Kaplan-Meier was used to calculate the survival. RESULTS: There were 36 patients with diagnosis of non-Hodgkin lymphoma of the female genital tract and followed for a median of 61 months (0-361 months). The median age of diagnosis was 44 years (19-87 years), and 76% (n = 28) were classified as stage IV.Of these, 4 patients were asymptomatic on presentation, and 13 were identified incidentally during surgery/radiography (n = 9), on prenatal ultrasound (n = 1), and on Papanicolaou test (n = 3). The location of the disease included the ovary (n = 6), uterine corpus and cervix (n= 9), vagina (n = 1), a pelvic mass (n = 7), isolated pelvic/para-aortic lymph nodes (n = 3), and/or multiple sites (n = 9). There were 6 cases that were concomitant with other gynecologic malignancies.Diffuse large B-cell lymphoma (n= 18) was the most common histologic type. A total of 28 patients underwent surgery. Combination chemotherapy was used in 34 patients, with concomitant radiation therapy in 7 and stem cell transplantation in 3. A total of 5 patients had recurrent disease.The overall median survival from the diagnosis of lymphoma was 70 months (0.3-361 months) with a 91% 1-year survival, 86% 5-year survival, and a 79% 10-year survival. CONCLUSIONS: Our report is the largest published single-institution experience of this disease. It demonstrates a more favorable prognosis and proposes that with early diagnosis and appropriate therapy, radical gynecologic surgery can be avoided.
First Page
1250
Last Page
5
DOI
10.1097/IGC.0000000000000201
Publication Date
9-1-2014
Recommended Citation
Ahmad, Asima Kaleem; Hui, Pei; Litkouhi, Babak; Azodi, Masoud; Rutherford, Thomas; McCarthy, Shirley; Xu, Mina LuQing; Schwartz, Peter E.; and Ratner, Elena, "Institutional review of primary non-hodgkin lymphoma of the female genital tract: a 33-year experience" (2014). Obstetrics and Gynecology. 138.
https://scholar.bridgeporthospital.org/obgyn/138
Identifier
25010039 (pubmed); NIHMS598668 (mid); PMC8139417 (pmc); 10.1097/IGC.0000000000000201 (doi); S1048-891X(24)03926-4 (pii)