Multimodality local ablative therapy of 23 lung metastases with surgical resection and percutaneous cryoablation in a patient with Li-Fraumeni Syndrome: A case report

Authors

Jonathan A. Saenger, Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA, USA.Follow
Ismail Tahir, Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA, USA.Follow
Manuela Födinger, Department of Radiology, Medical School, Sigmund Freud University, Vienna, Austria.
Gregory M. Cote, Department of Oncology, Massachusetts General Hospital, Boston, MA, USA.
Ashok Muniappan, Department of Surgery, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA.Follow
Florian J. Fintelmann, Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA, USA.Follow

Document Type

Article

Publication Title

Radiology case reports

Abstract

Patients with Li-Fraumeni syndrome (LFS) are prone to develop a variety of malignancies due to insufficient activity of the encoded tumor suppressor protein P53, including adrenocortical carcinoma, breast cancer, lung cancer, pancreatic cancer, and sarcoma. In the setting of LFS, local treatment options for lung metastases are limited to surgery and thermal ablation since radiotherapy and some systemic therapies predispose patients to additional future malignancies. We present the case of a 45-year-old woman with LFS with leiomyosarcoma metastases to both lungs who underwent bilateral wedge resections to treat a total of eight lung metastases followed by six percutaneous cryoablation sessions to treat 15 additional lung metastases over a period of 24 months. Our case demonstrates the option of multimodal local ablative therapies for lung metastases in patients with LFS, including percutaneous cryoablation.

First Page

3586

Last Page

3591

DOI

10.1016/j.radcr.2023.07.047

Publication Date

10-1-2023

Recommended Citation

Saenger, Jonathan A.; Tahir, Ismail; Födinger, Manuela; Cote, Gregory M.; Muniappan, Ashok; and Fintelmann, Florian J., "Multimodality local ablative therapy of 23 lung metastases with surgical resection and percutaneous cryoablation in a patient with Li-Fraumeni Syndrome: A case report" (2023). Radiology. 5.
https://scholar.bridgeporthospital.org/radiology/5

Identifier

37577077 (pubmed); PMC10415826 (pmc); 10.1016/j.radcr.2023.07.047 (doi); S1930-0433(23)00488-0 (pii)