Usefulness of radium-223 in patients with bone metastases

Nishant Gupta, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).Follow
Arushi Devgan, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).
Itisha Bansal, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).Follow
Thomas D. Olsavsky, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).Follow
Shuo Li, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).Follow
Ahmed Abdelbaki, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).Follow
Yogesh Kumar, Department of Radiology, Columbia University Medical Center, New York, New York (Gupta); Department of Radiology, University of Arkansas, Little Rock, Arkansas (Devgan); Department of Anesthesiology, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York (Bansal); Department of Nuclear Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut (Olsavsky); Department of Radiology, Yale New Haven Health at Bridgeport Hospital, Bridgeport, Connecticut (Li, Abdelbaki); and Columbia University at Bassett Healthcare, Cooperstown, New York (Kumar).Follow

Document Type

Article

Publication Title

Proceedings (Baylor University. Medical Center)

Abstract

Castration-resistant prostate osseous metastases can be challenging to treat. There is a new era of clinical advancement with the Food and Drug Administration approval of radium-223 for use in these patients. Radium-223 is the only clinically used therapeutic radiopharmaceutical that emits alpha particles, making it extremely safe for therapeutic purposes for the patient as well as close contacts. This review discusses radium-223's mechanism of action, pharmacokinetics, indications, and safety profile, as well as findings of concluded clinical trials.

First Page

424

Last Page

426

DOI

10.1080/08998280.2017.11930213

Publication Date

10-1-2017

Identifier

28966451 (pubmed); PMC5595381 (pmc); 10.1080/08998280.2017.11930213 (doi)

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