Cryoablation Without Excision for Early-Stage Breast Cancer: ICE3 Trial 5-Year Follow-Up on Ipsilateral Breast Tumor Recurrence
Document Type
Article
Publication Title
Annals of surgical oncology
Abstract
BACKGROUND: The ICE3 trial evaluated the safety and efficacy of cryoablation in women aged ≥60 years with low-risk, early-stage breast cancers, aiming to provide a non-operative treatment option and avoid potential surgical risks. This study presents 5-year follow-up trial results. METHODS: The ICE3 trial is an Institutional Review Board-approved, prospective, multicentered, non-randomized trial including women ≥ 60 years of age with unifocal, ultrasound visible, invasive ductal carcinoma ≤ 1.5 cm in size, histologic grade 1-2, hormone receptor (HR)-positive, and human epidermal growth factor receptor 2 (HER2)-negative. The primary study endpoint of 5-year ipsilateral breast tumor recurrence (IBTR) was evaluated based on Kaplan-Meier estimates. RESULTS: Overall, 194 patients meeting eligibility received successful cryoablation treatment per protocol and were included for analysis. The mean age was 74.9 years (55-94) with a mean tumor size of 7.4 mm transverse (2.8-14.0 mm) and 8.1 mm sagittal (2.5-14.9 mm). With a mean follow-up period of 54.16 months, the IBTR rate at 5 years was 4.3% and breast cancer survival was 96.7%. Of the 124 patients who received endocrine therapy only, the IBTR was 3.7%. No serious device-related adverse events were reported. Minor (88.2%) and moderate (9.6%) adverse events were mild in severity and resolved without residual effects. Quality-of-life score demonstrated statistically significant improvement (p < 0.001) in distress at 6 months as compared with baseline. CONCLUSIONS: Breast cryoablation presents a promising alternative to surgery in selected patients, offering the benefits of a minimally invasive procedure with minimal risks. Further studies are encouraged to confirm cryoablation as a viable alternative to surgical excision low-risk patients.
First Page
7273
Last Page
7283
DOI
10.1245/s10434-024-16181-0
Publication Date
10-1-2024
Recommended Citation
Fine, Richard E.; Gilmore, Richard C.; Tomkovich, Kenneth R.; Dietz, Jill R.; Berry, Michael P.; Hernandez, Lydia E.; Columbus, Karen S.; Seedman, Susan A.; Fisher, Carla S.; Han, Linda K.; Manahan, Eric R.; Hicks, Randy D.; Vaidya, Rashmi P.; Curcio, Lisa D.; Sevrukov, Alexander B.; Kenler, Andrew S.; Taback, Bret; Chen, Margaret; Miller, Megan E.; Gold, Linsey; Anglin, Beth V.; Aoun, Hussein D.; Simmons, Rache M.; Feldman, Sheldon M.; and Boolbol, Susan K., "Cryoablation Without Excision for Early-Stage Breast Cancer: ICE3 Trial 5-Year Follow-Up on Ipsilateral Breast Tumor Recurrence" (2024). Randomized Controlled Trial. 1.
https://scholar.bridgeporthospital.org/randomized_trial/1
Identifier
39283572 (pubmed); PMC11452421 (pmc); 10.1245/s10434-024-16181-0 (doi); 10.1245/s10434-024-16181-0 (pii)