Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis

Authors

Joseph A. Miccio, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.
Wesley J. Talcott, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.
Timil Patel, Department of Medical Oncology, Yale School of Medicine, New Haven, CT 06520, USA.
Henry S. Park, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Michael Cecchini, Department of Medical Oncology, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Ronald R. Salem, Department of Surgery, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Sajid A. Khan, Department of Surgery, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Stacey Stein, Department of Medical Oncology, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Jeremy S. Kortmansky, Department of Medical Oncology, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Jill Lacy, Department of Medical Oncology, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Amol Narang, Department of Radiation Oncology & Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joseph Herman, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Salma K. Jabbour, Department of Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
Christopher L. Hallemeier, Department of Radiation Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Kimberly Johung, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.Follow
Krishan R. Jethwa, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.

Document Type

Article

Publication Title

Clinical and translational radiation oncology

Abstract

PURPOSE: Margin-negative (R0) resection is the only potentially curative treatment for patients with pancreatic ductal adenocarcinoma (PDAC). Pre-operative multi-agent chemotherapy alone (MAC) or MAC followed by pre-operative radiotherapy (MAC + RT) may be used to improve resectability and potentially survival. However, the optimal pre-operative regimen is unknown. METHODS: Patients with non-metastatic PDAC from 2006 to 2016 who received pre-operative MAC or MAC + RT before oncologic resection were identified in the National Cancer Database. Univariable and multivariable (MVA) associates with R0 resection were identified with logistic regression, and survival was analyzed secondarily with the Kaplan Meier method and Cox regression analysis. RESULTS: 4,599 patients were identified (MAC: 3,109, MAC + RT: 1,490). Compared to those receiving MAC, patients receiving MAC + RT were more likely to have cT3-4 disease (76% vs 64%, p < 0.001) and cN + disease (33% vs 29%, p = 0.010), but were less likely to have ypT3-4 disease (59% vs 74%, p < 0.001) and ypN + disease (32% vs 55%, p < 0.001) and more likely to have a pathologic complete response (5% vs 2%, p < 0.001) and R0 resection (86% vs 80%, p < 0.001). On MVA, MAC + RT (OR 1.58, 95% CI 1.33-1.89, p < 0.001), evaluation at an academic center (OR 1.33, 95% CI 1.14-1.56, p < 0.001), and female sex (OR 1.43, 95% CI 1.23-1.67, p < 0.001) were associated with higher odds of R0 resection, while cT3-4 disease (OR 0.81, 95% CI 0.68-0.96, p = 0.013) was associated with lower odds of R0 resection. CONCLUSION: For patients with localized PDAC who receive pre-operative MAC, the addition of pre-operative RT was associated with improved rates of R0 resection and pathologic response.

First Page

15

Last Page

23

DOI

10.1016/j.ctro.2020.12.003

Publication Date

3-1-2021

Recommended Citation

Miccio, Joseph A.; Talcott, Wesley J.; Patel, Timil; Park, Henry S.; Cecchini, Michael; Salem, Ronald R.; Khan, Sajid A.; Stein, Stacey; Kortmansky, Jeremy S.; Lacy, Jill; Narang, Amol; Herman, Joseph; Jabbour, Salma K.; Hallemeier, Christopher L.; Johung, Kimberly; and Jethwa, Krishan R., "Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis" (2021). Surgery. 219.
https://scholar.bridgeporthospital.org/surgery/219

Identifier

33392398 (pubmed); PMC7772693 (pmc); 10.1016/j.ctro.2020.12.003 (doi); S2405-6308(20)30106-3 (pii)