Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer

Authors

Rebecca Zhu, Yale University School of Medicine, New Haven, CT, USA. R.Zhu@yale.edu.Follow
Gabriella Grisotti, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA. Gabriella.Grisotti@yale.edu.Follow
Ronald R. Salem, Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, PO BOX 208062, New Haven, CT, USA. Ronald.Salem@yale.edu.Follow
Sajid A. Khan, Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, PO BOX 208062, New Haven, CT, USA. Sajid.Khan@yale.edu.Follow

Document Type

Article

Publication Title

World journal of surgical oncology

Abstract

BACKGROUND: Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut. CASE PRESENTATION: We report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature. CONCLUSIONS: Locally advanced colorectal cancer in HNPCC is a rare clinical entity that requires special surgical consideration. Multidisciplinary treatment, including multi-visceral resection, offers the best long-term outcome.

First Page

12

DOI

10.1186/s12957-015-0755-7

Publication Date

1-15-2016

Recommended Citation

Zhu, Rebecca; Grisotti, Gabriella; Salem, Ronald R.; and Khan, Sajid A., "Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer" (2016). Surgery. 224.
https://scholar.bridgeporthospital.org/surgery/224

Identifier

26769110 (pubmed); PMC4714509 (pmc); 10.1186/s12957-015-0755-7 (doi); 10.1186/s12957-015-0755-7 (pii)