RISING USE OF IMMUNE CHECKPOINT INHIBITORS AND THE ESCALATING BURDEN OF GASTROINTESTINAL AND HEPATIC TOXICITIES: A NINE-YEAR ANALYSIS

Authors

Donghyun Ko, Department of Internal Medicine, Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA.
Do Han Kim MD, Department of Medicine, Mount Sinai Morningside and West, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Pedro Palacios Argueta MD, Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Wilhelm S. Basegoda MD, University of South Alabama, Mobile, AL, USA
Jose A. Porres, Universidad Francisco Marroquin, Guatemala City, Guatemala.
Francis F. Fadi, Mayo Clinic's Campus in Florida, Jacksonville, FL, United States
Jana G. Hashash, Mayo Clinic's Campus in Florida, Jacksonville, FL, United States
Francis A. Farraye, Mayo Clinic's Campus in Florida, Jacksonville, FL, United States
Paul T. Kroner MD, Department of Gastroenterology, Riverside Health System, Newport News, VA, USA.

Document Type

Conference Proceeding

Abstract

The advent of immune checkpoint inhibitors (ICIs), including programmed death 1 (PD-1), PD-L1, and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitors, has revolutionized cancer therapeutics, markedly improving survival in various malignancies. However, their expanding utilization has been paralleled by the emergence of immune-related adverse events (irAEs), particularly gastrointestinal (GI) and hepatic toxicities, which pose significant challenges in clinical practice. These toxicities can manifest as a spectrum of conditions, from mild transient symptoms to severe, life-threatening complications, necessitating a better understanding of their prevalence and trends. This study aims to evaluate the temporal changes in ICI use and associated GI and hepatic adverse events over a nine year period using a large population-based dataset

Publication Date

5-2025

Recommended Citation

Ko, Donghyun; Kim, Do Han MD; Palacios Argueta, Pedro MD; Basegoda, Wilhelm S. MD; Porres, Jose A.; Fadi, Francis F.; Hashash, Jana G.; Farraye, Francis A.; and Kroner, Paul T. MD, "RISING USE OF IMMUNE CHECKPOINT INHIBITORS AND THE ESCALATING BURDEN OF GASTROINTESTINAL AND HEPATIC TOXICITIES: A NINE-YEAR ANALYSIS" (2025). Posters. 104.
https://scholar.bridgeporthospital.org/poster_presentations/104