Document Type
Conference Proceeding
Abstract
The use of immune checkpoint inhibitors (ICI) in recent years has increasingly emerged as a second-line treatment in the management of extensive-stage small cell lung cancer (ES-SCLC) compared to conventional chemotherapy alone.
The use of combined ICI therapy by inhibiting two distinct pathways in patients with ES-SCLC has been evaluated in clinical trials. The increase incidence of immune related adverse events (Ir-AE) in these trials due to excessive immune system activation or multiple organ disorders has posed serious clinical challenges.
Here we report a dramatic and durable response to combined immune checkpoint blockade without chemotherapy and discuss the relationship between severe ICI toxicity and durable response as well as potential role of anti-neuronal antigen immune activation producing profound anti-tumor effect but also leading to severe autoimmune toxicity
Publication Date
Spring 2025
Recommended Citation
Lobo, Aaron MD; Rahman, Nur MD; Blondin, Nicholas MD; and Fischbach, Neal, "Single dose nivolumab and ipilimumab treatment causing complete and durable response in extensive stage - small cell lung cancer complicated by severe sensory autoimmune neuropathy" (2025). Posters. 65.
https://scholar.bridgeporthospital.org/poster_presentations/65
Included in
Medical Pharmacology Commons, Oncology Commons, Pulmonology Commons
Comments
Presented at: NCCN 2025