Document Type

Conference Proceeding

Abstract

The use of immune checkpoint inhibitors (ICI) in recent years has increasingly emerged as a second-line treatment in the management of extensive-stage small cell lung cancer (ES-SCLC) compared to conventional chemotherapy alone.

The use of combined ICI therapy by inhibiting two distinct pathways in patients with ES-SCLC has been evaluated in clinical trials. The increase incidence of immune related adverse events (Ir-AE) in these trials due to excessive immune system activation or multiple organ disorders has posed serious clinical challenges.

Here we report a dramatic and durable response to combined immune checkpoint blockade without chemotherapy and discuss the relationship between severe ICI toxicity and durable response as well as potential role of anti-neuronal antigen immune activation producing profound anti-tumor effect but also leading to severe autoimmune toxicity

Publication Date

Spring 2025

Comments

Presented at: NCCN 2025

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